Aftar PSV had been removed from the Cup tournament due to an administrative error (the team had fielded ineligible player Manuel Da Costa), another favorite left the stage. AZ were eliminated by Cambuur, 1-0.
The complete draw is as follows:

ADO Den Haag - Young sc Heerenveen
Heracles Almelo - FC Omniworld
MVV - FC Dordrecht
Feyenoord - FC Groningen
Fortuna Sittard - FC Den Bosch
FC Zwolle - Go Ahead Eagles
Cambuur Leeuwarden - Excelsior
FC Eindhoven - HFC Haarlem
De Treffers - NEC
Deurne - UNA
HHC Hardenberg - AGOVV Apeldoorn
Groene Ster - Quick Boys
Roda JC - De Graafschap
Sparta - NAC Breda
Ajax - sc Heerenveen
RKC Waalwijk - BV Veendam